منابع مشابه
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GSK1322322 (N-((R)-2-(cyclopentylmethyl)-3-(2-(5-fluoro-6-((S)-hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl)-2-methylpyrimidin-4-yl) hydrazinyl)-3-oxopropyl)-N-hydroxy-formamide) is an antibiotic in development by GlaxoSmithKline. In this study, we investigated the metabolism and disposition of [C]GSK1322322 in healthy humans and demonstrated the utility of the Entero-Test in a human radiolabel...
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Several nuclear receptor (NR) superfamily members are known to be the molecular target of either the small ubiquitin-related modifier (SUMO) or ubiquitin-signaling pathways. However, little is currently known regarding how these two post-translational modifications interact to control NR biology. We show that SUMO and ubiquitin circuitry coordinately modifies the pregnane X receptor (PXR, NR1I2...
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The tumour suppressor gene lethal (2) giant discs (lgd) is involved in endosomal trafficking of transmembrane proteins in Drosophila. Loss of function results in the ligand-independent activation of the Notch pathway in all imaginal disc cells and follicle cells. Analysis of lgd loss of function has largely been restricted to imaginal discs and suggests that no other signalling pathway is affec...
متن کامل1325 - 9547 towards a Knowledge Economy
This paper provides a preliminary formulation of a new currency based on knowledge. Through a literature review of alternative currencies, various properties and benefits are selected that we hope will enable such a currency to be created. Nowadays not only money but also knowledge is necessary to do business. For instance, knowledge about markets and consumers is highly valuable but difficult ...
متن کاملIMIT 2 G 1325 VoiceXML For : Professor Gerald
Today VoiceXML is the standard scripting language for rendering web pages over the telephone. Developing costs of an interactive phone application have changed dramatically with the new markup language. VoiceXML builds on the basic concept and rules set by XML. Interactive applications contain synthesized speech, pre-recorded audio, grammars defining words that could be recognised, and DTMF key...
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ژورنال
عنوان ژورنال: CONTEMPORARY MILITARY CHALLENGES
سال: 2016
ISSN: 2463-9575,2232-2825
DOI: 10.33179//bsv.99.svi.11.cmc.18.3.1